Dominant anonychia and onychodystrophy.

Case 1. The grandfather, II.3, born in 1889, suffers from lymphatic leukaemia and diabetes. As can be seen in Fig. 2a, the hands show complete anonychia of the thumb, the forefinger, and the middle finger, with nail-bed vestiges present as small ridges on the outer finger edges. The fourth and fifth fingers show the absence of nails in the central part, and two small atrophied nail lamellae on the sides. In the feet, Fig. 2b, there was total anonychia on the big toe, a rudimentary ridge on the second right toe, thin, narrow nail lamellae on the second and third toes, and hypoplastic nails on the third and fourth toes. The bulging aspect of the terminal phalanges on the first, second, and third toes is noteworthy. Case 2. The daughter, III.6 born in 1926, is obese. In the hands (Fig. 3a) there was total anonychia on the forefinger and the middle finger of the right hand, and on the left forefinger (with small sunken areas on the sides, corresponding to the nail edge); nail rudiments, nearly punctiform, on both thumbs and hypoplastic nails on the fourth fingers, while the fifth fingers had normal nails. The feet (Fig. 3b) showed total absence of nails and nail beds on the first and second right toes, hypoplastic nails on the other toes, the degree of hypoplasia decreasing towards the ends.